DAMEfinder: a method to detect differential allele-specific methylation
نویسندگان
چکیده
منابع مشابه
Direct Bisulfite Sequencing and Methylation Specific PCR to Detect Methylation of p15INK4b and F7 genes in Coronary Artery Disease Patients
Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the ...
متن کاملRapid and quantitative method of allele-specific DNA methylation analysis.
Several biological phenomena depend on differential methylation of chromosomal strands. While understanding the role of these processes requires information on allele-specific methylation, the available methodologies are not quantitative or labor-intensive. We describe a novel, rapid method to quantitate allele-specific DNA methylation based on the combination of bisulfite PCR and Pyrosequencin...
متن کاملAllele-specific DNA methylation: beyond imprinting.
Allele-specific DNA methylation (ASM) and allele-specific gene expression (ASE) have long been studied in genomic imprinting and X chromosome inactivation. But these types of allelic asymmetries, along with allele-specific transcription factor binding (ASTF), have turned out to be far more pervasive-affecting many non-imprinted autosomal genes in normal human tissues. ASM, ASE and ASTF have now...
متن کاملdirect bisulfite sequencing and methylation specific pcr to detect methylation of p15ink4b and f7 genes in coronary artery disease patients
genome-wide association studies (gwas) have identified genetic variants contributing to the risk of cardiovascular disease (cvd) at the chromosome 9p21 locus. the chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (cad). f7 gene because of its role in activating the ...
متن کاملMonoallelic methylation and allele specific expression in a social insect
Social insects are emerging models for epigenetics. Here we examine the link between monoallelic methylation and monoallelic expression in the bumblebee Bombus terrestris using whole methylome and transcriptome analysis. We found nineteen genes displaying monoallelic methylation and expression. They were enriched for functions to do with social organisation in the social insects. These are the ...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2020
ISSN: 1756-8935
DOI: 10.1186/s13072-020-00346-8